Ana Magalhães
Name: Ana Magalhães
E-mail: amagalhaes@i3s.up.pt
Extension: 
225570700
Academic Degree: PhD


Ana Magalhães
Ana Magalhães
Member of
Affiliated Researcher of Glycobiology in Cancer


Short CV

Ana Magalhães graduated in Biochemistry (2005) and obtained a PhD in Biomedicine (2011) from the University of Porto. She received advanced training in cancer glycobiology at IPATIMUP under the mentorship of Prof. Celso Reis, and in glycan-mediated bacterial adhesion at Umeå University (Sweden) in the laboratory of Prof. Thomas Borén. She is currently Associate Professor of Biochemistry at School of Medicine and Biomedical Sciences of University of Porto (ICBAS) and Senior Researcher at Institute for Research and Innovation in Health (i3S). Her research has significantly contributed to elucidating the role of glycans in gastric pathology, including their function as receptors for the oncogenic bacterium Helicobacter pylori and their involvement in cancer cell signalling, extracellular-communication and metastasis. Ana has co-authored over 50 scientific publications in journals, such as Cancer Cell, PNAS, Nature Cell Biology and Journal of Biological Chemistry. Her work has received more than 3500 citations (H-index 36). She has successfully supervised 6 PhD and 8 MSc students as main or co-supervisor (ORCID: 0000-0003-4863-6668). Over the past five years, Ana has been leading a research team dedicated to investigating glycosaminoglycans (GAGs) in gastric cancer, with a strong focus on translating fundamental discoveries into clinical applications. Her team has shown that dysregulation of GAG biosynthetic pathways drives aggressive tumour behaviour and identified the proteoglycan SDC4 as a biomarker of poor prognosis associated with tumour dissemination. Ana has solid experience in scientific projects coordination and research management and has participated in several European consortia, including GASTRIC GLYCO EXPLORER MSCA-DN and INNOGLY COST action. She is also committed to science outreach and enjoys engaging regularly with younger audiences through school visits to talk about science and organize hands-on science activities in the laboratory (Ciencia Viva and Universidade Junior).


Highlights
Identification of Syndecan-4 functional role in Helicobacter pylori adhesion and injection of virulence factors.

Glycophenotype characterization of human gastric mucosas representing different stages of the gastric carcinogenic cascade. We aim to find combinations of glycans that are differently expressed according to disease stage and to identify glycoforms selected by gastric cancer cells.

Understanding of the biological relevance of sialylated glycan structures in modulating gastric cancer cell behaviour and putative involvement in gastric carcinogenesis.

Designing of novel therapeutic strategies to prevent bacterial binding which explore the H. pylori-host glycans interactions.

Supervisor of
Ana Ribeiro, PhD Student
PhD student
Catarina Marques, Assistant Professor
Temporary
João Mota, MSc student
Temporary
Rita Marinho, Research Trainee
Temporary

PI (running)

PI (closed)
First Author
 
C
IF
The role of O-glycosylation in human disease. Molecular aspects of medicine 79: 100964, 2021. [Review] 
 
Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer cell 31: 733-735, 2017. [Editorial Material] 
 
3. Magalhães A, Rossez Y, Robbe-Masselot C, Maes E, Gomes J, Shevtsova A, Bugaytsova J, Borén T, Reis CA
 doi: 10.1038/srep25575 PMID: 27161092.
 
4. Magalhães A, Mereiter S, Reis C
 
5. Magalhães A, Marcos-Pinto R, Nairn AV, Dela Rosa M, Ferreira RM, Junqueira-Neto S, Freitas D, Gomes J, Oliveira P, Santos MR, Marcos NT, Xiaogang W, Figueiredo C, Oliveira C, Dinis-Ribeiro M, Carneiro F, Moremen KW, David L, Reis CA
Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852: 1928-39, 2015. [Article] 
 
Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 43: 611-8, 2010. [Review] 
 PMID: 20521012.
 
7. Magalhães A, Ismail MN, Reis CA
Sweet receptors mediate the adhesion of the gastric pathogen Helicobacter pylori: glycoproteomic strategies. Expert review of proteomics 7: 307-10, 2010. [Editorial Material] 
 doi: 10.1586/epr.10.18 PMID: 20536299.
 
8. Magalhães A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osório H, David L, Le Pendu J, Haas R, Dell A, Borén T, Reis CA
 
9. Magalhães A, Marcos N T, Carvalho A S, David L, Figueiredo C, Bastos J, David G, Reis C
 
Senior Author
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