Manuel Sobrinho-Simões
Name: Manuel Sobrinho-Simões
E-mail: ssimoes@ipatimup.pt
Extension: 
225570700
Academic Degree: Phd, MD, Agg


Manuel Sobrinho-Simões
Manuel Sobrinho-Simões
Member of
Coordinator of Ipatimup Diagnostics
Researcher of Cancer Signalling & Metabolism


Short CV

Manuel Sobrinho Simões MD, PhD, HonFRCPath, is Emeritus Professor of Pathology of the Medical Faculty and Director of the IPATIMUP since its creation in 1989. He co-created i3S in 2008 under the auspices of Porto University. MSS chaired the National Council of Clinical Academic Centers and chaired the Board of the National Agency for Evaluation and Accreditation of Higher Education (A3ES) between 2017 and 2021. MSS is co-author of 440 scientific publications which have given rise to more than 19000 citations (h factor >71). His main interests are oncobiology and thyroid cancer. MSS carries about 300 diagnostic consultations per year for foreign institutions.

MSS was President of the European Society of Pathology from 1999 to 2001, after having been Secretary from 1989 to 1997.He helped creating EUROCELLPATH (European Courses on Cellular Pathology) and the European School of Pathology (EScoP), and has been co-organizing Courses on Thyroid Tumours in Europe, South America, Asia and USA since 1992. MSS has co-authored many chapters of three editions (1988,2006,2017,2022) of the WHO Book on Endocrine Tumours. He has been elected by his peers “The most influent pathologist” in a survey conducted in 2015 by “The Pathologist”. 

Highlights

Supervisor of

PI (running)

PI (closed)
Estudo clínico, patológico e molecular para otimizar o tratamento do carcinoma diferenciado da tiroide.
Atenção integrada ao doente oncológico no Hospital Central de Maputo - Reforço da capacidade institucional
Acções de Colaboração com instituições norte-americanas durante o ano de 2012
Identificação de factores prognósticos e de selecção terapêutica em carcinomas diferenciados da tireoide
Study of the role played by TGF-B dual effect in the progression of papillary thyroid carcinoma
Prevention and early diagnosis of cancer
Reforço das capacidades institucionais do Serviço de Anatomia Patológica do Hospital Central de Maputo
Mapping of genes predisposing to familial thyroid tumours
Prevention and early diagnosis of cancer and precancerous lesions of cervix, stomach, breast and thyroid - co-financiamento EFTA
Acções de Colaboração com instituições norte-americanas durante o ano de 2008
O cancro e as lesões precancerosas do estômago na China
Partilha entre o IPATIMUP, IBMC e INEB
First Author
 
C
IF
1. Sobrinho-Simões M, Eloy C, Amendoeira I, Soares P, Caneiro-Gómez J, Melo M, Cameselle-Teijeiro JM
Introduction Rare Tumors of the Thyroid Gland: Diagnosis and WHO Classification  1-4, 2017. [] 
 doi: 10.1007/978-3-319-61182-2_1.
 
0
-
2. Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Follicular thyroid carcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 24 Suppl 2: S10-8, 2011. [Article] 
 doi: 10.1038/modpathol.2010.133 PMID: 21455197.
 
98
4.8
3. Sobrinho-Simões M, Magalhães J, Soares P
Hot topics in papillary thyroid carcinoma. International journal of surgical pathology 18: 190S-193S, 2010. [Article; Proceedings Paper] 
 doi: 10.1177/1066896910370882 PMID: 20484289.
 
0
1.1
4. Sobrinho-Simões M, Máximo V, Rocha AS, Trovisco V, Castro P, Preto A, Lima J, Soares P
Intragenic mutations in thyroid cancer. Endocrinology and metabolism clinics of North America 37: 333-62, viii, 2008. [Review] 
 doi: 10.1016/j.ecl.2008.02.004 PMID: 18502330.
 
75
2.1
5. Sobrinho-Simões M, Máximo V
Warthin's tumour. Virchows Archiv : an international journal of pathology 448: 877-8, 2006. [Letter] 
 doi: 10.1007/s00428-005-0052-x PMID: 16609912.
 
8
2.3
6. Sobrinho-Simões M, Máximo V, Castro IV, Fonseca E, Soares P, Garcia-Rostan G, Oliveira MC
Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance. International journal of surgical pathology 13: 29-35, 2005. [Review] 
 PMID: 15735852.
 
53
0.9
7. Sobrinho-Simões M, Preto A, Rocha AS, Castro P, Máximo V, Fonseca E, Soares P
Molecular pathology of well-differentiated thyroid carcinomas. Virchows Archiv : an international journal of pathology 447: 787-93, 2005. [Review] 
 doi: 10.1007/s00428-005-0065-5 PMID: 16189702.
 
49
2.2
8. Sobrinho-Simões M
Funding of a medical research institute in a small country: 15 years of Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP)--interview conducted by Ivan Damjanov. Croatian medical journal 46: 467-75, 2005. [] 
 PMID: 15861529.
 
0
0.8
9. Sobrinho-Simões M, Sambade C, Fonseca E, Soares P
Poorly differentiated carcinomas of the thyroid gland: a review of the clinicopathologic features of a series of 28 cases of a heterogeneous, clinically aggressive group of thyroid tumors. International journal of surgical pathology 10: 123-31, 2002. [Article] 
 PMID: 12075405.
 
49
0.7
10. Sobrinho-Simões M, Oliveira C
Different types of epithelial cadherin alterations play different roles in human carcinogenesis. Advances in anatomic pathology 9: 329-37, 2002. [Article] 
 PMID: 12409641.
 
7
1.8
11. Sobrinho-Simões M
Difficult cases of thyroid pathology. Endocrine pathology 13: 369-70; author reply 371, 2002. [Letter] 
 PMID: 12665655.
 
1
0.4
12. Sobrinho-Simões M
Hail to the histologic grading of papillary thyroid carcinoma? Cancer 88: 1766-8, 2000. [Editorial Material] 
 PMID: 10760750.
 
4
3.6
13. Sobrinho Simões M, Ribeiro P
Venous invasion as a prognostic factor in colorectal carcinoma European journal of cancer (Oxford, England : 1990) 33: 729-729, 1997. [Meeting Abstract] 
.
 
0
-
14. David L, Sobrinho Simões M
Tenascin and oncofetal fibronectin--oncofetal markers or indicators of extracellular matrix remodelling? British journal of cancer 74: 990-1, 1996. [Letter] 
 PMID: 8826873.
 
1
-
15. Sobrinho-Simoes M
Mixed medullary and follicular carcinoma of the thyroid. Histopathology 23: 287-9, 1993. [Note] 
 PMID: 8225250.
 
20
-
Senior Author
 
C
IF
1. Eloy C, Vale J, Curado M, Polónia A, Campelos S, Caramelo A, Sousa R, Sobrinho-Simões M
Digital Pathology Workflow Implementation at IPATIMUP. Diagnostics (Basel, Switzerland) 11: ., 2021. [Article] 
 doi: 10.3390/diagnostics11112111 PMID: 34829458.
 
25
3.7 (*)
2. Soares P, Póvoa AA, Melo M, Vinagre J, Máximo V, Eloy C, Cameselle-Teijeiro JM, Sobrinho-Simões M
Molecular Pathology of Non-familial Follicular Epithelial-Derived Thyroid Cancer in Adults: From RAS/BRAF-like Tumor Designations to Molecular Risk Stratification. Endocrine pathology 32: 44-62, 2021. [Review] 
 doi: 10.1007/s12022-021-09666-1 PMID: 33651322.
 
14
3.9 (*)
3. Correia M, Lima AR, Batista R, Máximo V, Sobrinho-Simões M
Inherited Thyroid Tumors With Oncocytic Change. Frontiers in endocrinology 12: 691979, 2021. [Review] 
 doi: 10.3389/fendo.2021.691979 PMID: 34177813.
 
2
5.6 (*)
4. Cameselle-Teijeiro JM, Eloy C, Sobrinho-Simões M
Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers. Endocrine pathology 31: 197-217, 2020. [Article] 
 doi: 10.1007/s12022-020-09638-x PMID: 32632840.
 
8
3.2 (*)
5. Cameselle-Teijeiro JM, Sobrinho-Simões M
Cribriform-morular variant of thyroid carcinoma. Pathologica 111: 1-3, 2019. [Editorial Material] 
 doi: 10.32074/1591-951X-66-18 PMID: 31217615.
 
2
-
6. Amendoeira I, Maia T, Sobrinho-Simões M
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): impact on the reclassification of thyroid nodules. Endocrine-related cancer 25: R247-R258, 2018. [Review] 
 doi: 10.1530/ERC-17-0513 PMID: 29439059.
 
35
5.3 (*)
7. Cameselle-Teijeiro JM, Sobrinho-Simões M
New WHO classification of thyroid tumors: a pragmatic categorization of thyroid gland neoplasms. Endocrinologia, diabetes y nutricion 65: 133-135, 2018. [Editorial Material] 
 doi: 10.1016/j.endinu.2017.11.012 PMID: 29396216.
 
18
0.0 (*)
8. Gullo I, Batista R, Rodrigues-Pereira P, Soares P, Barroca H, do Bom-Sucesso M, Sobrinho-Simões M
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations. American journal of clinical pathology 149: 379-386, 2018. [Article] 
 doi: 10.1093/ajcp/aqy004 PMID: 29538609.
 
17
2.4 (*)
9. Canberk S, Pereira L, Batista R, Soares P, Maximo V, Simoes MS
DICER1 alterations are more frequent in oncocytic, follicular and rare aggressive variants than in classical papillary thyroid carcinoma Virchows Archiv 473: S67-S67, 2018. [Meeting Abstract] 
.
 
0
2.9 (*)
10. Cameselle-Teijeiro JM, Rodríguez-Pérez I, Celestino R, Eloy C, Piso-Neira M, Abdulkader-Nallib I, Soares P, Sobrinho-Simões M
Hobnail Variant of Papillary Thyroid Carcinoma: Clinicopathologic and Molecular Evidence of Progression to Undifferentiated Carcinoma in 2 Cases. The American journal of surgical pathology 41: 854-860, 2017. [Article] 
 doi: 10.1097/PAS.0000000000000793 PMID: 28009606.
 
25
5.9
11. Cameselle-Teijeiro JM, Eloy C, Amendoeira I, Soares P, Caneiro-Gómez J, Melo M, Sobrinho-Simões M
Other Rare Tumours and Tumour-Like Lesions Rare Tumors of the Thyroid Gland: Diagnosis and WHO Classification  79-105, 2017. [] 
 doi: 10.1007/978-3-319-61182-2_6.
 
0
-
12. Melo M, Cameselle-Teijeiro JM, Eloy C, Amendoeira I, Soares P, Caneiro-Gómez J, Sobrinho-Simões M
Therapeutic options Rare Tumors of the Thyroid Gland: Diagnosis and WHO Classification  107-110, 2017. [] 
 doi: 10.1007/978-3-319-61182-2_7.
 
0
-
13. Eloy C, Cameselle-Teijeiro JM, Amendoeira I, Soares P, Caneiro-Gómez J, Melo M, Sobrinho-Simões M
Small cell tumours Rare Tumors of the Thyroid Gland: Diagnosis and WHO Classification  45-56, 2017. [] 
 doi: 10.1007/978-3-319-61182-2_4.
 
0
-
14. Cameselle-Teijeiro JM, Eloy C, Amendoeira I, Soares P, Caneiro-Gómez J, Melo M, Sobrinho-Simões M
Rare papillary thyroid carcinomas Rare Tumors of the Thyroid Gland: Diagnosis and WHO Classification  5-25, 2017. [] 
 doi: 10.1007/978-3-319-61182-2_2.
 
0
-
15. Cameselle-Teijeiro JM, Eloy C, Amendoeira I, Soares P, Carneiro-Gómez J, Melo M, Sobrinho-Simões M
Rare familial tumours Rare Tumors of the Thyroid Gland: Diagnosis and WHO Classification  57-77, 2017. [] 
 doi: 10.1007/978-3-319-61182-2_5.
 
0
-
16. Eloy C, Soares P, Máximo V, Sobrinho-Simões M
Thyroid and parathyroid glands Pathology of the Head and Neck  613-671, 2017. [] 
 doi: 10.1007/978-3-662-49672-5_14.
 
0
-
17. Tavares C, Melo M, Cameselle-Teijeiro JM, Soares P, Sobrinho-Simões M
ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome. European journal of endocrinology 174: R117-26, 2016. [Review] 
 doi: 10.1530/EJE-15-0605 PMID: 26510840.
 
50
4.1
18. Ortiz S, Tortosa F, Sobrinho Simões M
An extraordinary case of mesenchymal chondrosarcoma metastasis in the thyroid. Endocrine pathology 26: 33-6, 2015. [Article] 
 doi: 10.1007/s12022-014-9351-6 PMID: 25510635.
 
4
1.8
19. Eloy C, Ferreira L, Salgado C, Soares P, Sobrinho-Simões M
Poorly Differentiated and Undifferentiated Thyroid Carcinomas. Tu¨rk patoloji dergisi 31 Suppl 1: 48-59, 2015. [Article] 
 doi: 10.5146/tjpath.2015.01314 PMID: 26177317.
 
0
-
20. Soares P, Celestino R, Gaspar da Rocha A, Sobrinho-Simões M
Papillary Thyroid Microcarcinoma: How to Diagnose and Manage this Epidemic? International journal of surgical pathology 22: 113-9, 2014. [Article] 
 doi: 10.1177/1066896913517394 PMID: 24401191.
 
41
1.0
21. Soares P, Celestino R, Melo M, Fonseca E, Sobrinho-Simões M
Prognostic biomarkers in thyroid cancer. Virchows Archiv : an international journal of pathology 464: 333-46, 2014. [Review] 
 doi: 10.1007/s00428-013-1521-2 PMID: 24487783.
 
38
2.7
22. Máximo V, Rios E, Sobrinho-Simões M
Oncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands. International journal of surgical pathology 22: 33-6, 2014. [Review] 
 doi: 10.1177/1066896913517938 PMID: 24406625.
 
26
1.0
23. Eloy C, Oliveira M, Vieira J, Teixeira MR, Cruz J, Sobrinho-Simões M
Carcinoma of the thyroid with ewing family tumor elements and favorable prognosis: report of a second case. International journal of surgical pathology 22: 260-5, 2014. [Article] 
 doi: 10.1177/1066896913486696 PMID: 23637256.
 
20
1.0
24. Nakazawa T, Cameselle-Teijeiro J, Vinagre J, Soares P, Rousseau E, Eloy C, Sobrinho-Simões M
C-cell-derived calcitonin-free neuroendocrine carcinoma of the thyroid: the diagnostic importance of CGRP immunoreactivity. International journal of surgical pathology 22: 530-5, 2014. [Article] 
 doi: 10.1177/1066896914525228 PMID: 24599901.
 
19
1.0
25. Eloy C, Cruz J, Vieira J, Teixeira MR, Cameselle-Teijeiro J, Sobrinho-Simões M
Carcinoma of the Thyroid With Ewing/PNET Family Tumor Elements: A Tumor of Unknown Histogenesis. International journal of surgical pathology 22: 579-81, 2014. [Letter] 
 doi: 10.1177/1066896913486697 PMID: 23637257.
 
14
1.0
26. Eloy C, Cameselle-Teijeiro JM, Rousseau E, Sobrinho-Simões M
Small cell tumors of the thyroid gland: a review. International journal of surgical pathology 22: 197-201, 2014. [Review] 
 doi: 10.1177/1066896913510029 PMID: 24275884.
 
8
1.0
27. Barroca H, Souto Moura C, Lopes JM, Lisboa S, Teixeira MR, Damasceno M, Bastos P, Sobrinho-Simões M
PNET with neuroendocrine differentiation of the lung: Report of an unusual entity. International journal of surgical pathology 22: 427-33, 2014. [Article] 
 doi: 10.1177/1066896913502227 PMID: 24141023.
 
6
1.0
28. Nakazawa T, Celestino R, Machado JC, Cameselle-Teijeiro JM, Vinagre J, Eloy C, Benserai F, Lameche S, Soares P, Sobrinho-Simões M
Cribriform-morular variant of papillary thyroid carcinoma displaying poorly differentiated features. International journal of surgical pathology 21: 379-89, 2013. [Article] 
 doi: 10.1177/1066896912473355 PMID: 23349472.
 
26
1.0
29. Bialas M, Okon K, Dyduch G, Ciesielska-Milian K, Buziak M, Hubalewska-Dydejczyk A, Sobrinho-Simoes M
Neuroendocrine markers and sustentacular cell count in benign and malignant pheochromocytomas - a comparative study. Polish journal of pathology : official journal of the Polish Society of Pathologists 64: 129-35, 2013. [Article] 
 PMID: 23900871.
 
13
0.8
30. Vilallonga R, Zafon C, Ruiz-Marcellan C, Obiols G, Fort JM, Baena JA, Villanueva B, Garcia A, Sobrinho-Simões M
Malignant thyroid teratoma: report of an aggressive tumor in a 64-year-old man. Endocrine pathology 24: 132-5, 2013. [Article] 
 doi: 10.1007/s12022-013-9250-2 PMID: 23702575.
 
7
1.6
31. Máximo V, Lima J, Prazeres H, Soares P, Sobrinho-Simões M
The biology and the genetics of Hurthle cell tumors of the thyroid. Endocrine-related cancer 19: R131-47, 2012. [Review] 
 doi: 10.1530/ERC-11-0354 PMID: 22514109.
 
49
5.3
32. Eloy C, Santos J, Cameselle-Teijeiro J, Soares P, Sobrinho-Simões M
TGF-beta/Smad pathway and BRAF mutation play different roles in circumscribed and infiltrative papillary thyroid carcinoma. Virchows Archiv : an international journal of pathology 460: 587-600, 2012. [Article] 
 doi: 10.1007/s00428-012-1234-y PMID: 22527019.
 
35
2.7
33. Cameselle-Teijeiro J, Caramés-Díaz N, Eloy C, Sobrinho-Simões M
C-cell hyperplasia and papillary thyroid carcinoma. International journal of surgical pathology 20: 643-4, 2012. [Letter] 
 doi: 10.1177/1066896912463167 PMID: 23172165.
 
0
0.8
34. Cameselle-Teijeiro J, Ferreira R, Caramés N, Abdulkader I, Máximo V, Soares P, Sobrinho-Simões M
Absence of the BRAF and the GRIM-19 Mutations in Oncocytic (Hurthle Cell) Solid Cell Nests of the Thyroid. American journal of clinical pathology 137: 612-8, 2012. [Article] 
 doi: 10.1309/AJCPB0RXYPACLL5K PMID: 22431538.
 
0
2.9
35. Soares P, Lima J, Preto A, Castro P, Vinagre J, Celestino R, Couto JP, Prazeres H, Eloy C, Máximo V, Sobrinho-Simões M
Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas. Current genomics 12: 609-17, 2011. [Article] 
 doi: 10.2174/138920211798120853 PMID: 22654560.
 
64
2.4
36. Eloy C, Santos J, Soares P, Sobrinho-Simões M
The preeminence of growth pattern and invasiveness and the limited influence of BRAF and RAS mutations in the occurrence of papillary thyroid carcinoma lymph node metastases. Virchows Archiv : an international journal of pathology 459: 265-76, 2011. [Article] 
 doi: 10.1007/s00428-011-1133-7 PMID: 21796448.
 
51
2.5
37. Cruz J, Eloy C, Aragüés JM, Vinagre J, Sobrinho-Simões M
Small-cell (basaloid) thyroid carcinoma: a neoplasm with a solid cell nest histogenesis? International journal of surgical pathology 19: 620-6, 2011. [Article] 
 doi: 10.1177/1066896911405320 PMID: 21531696.
 
24
1.0
38. Soares P, Sobrinho-Simões M
Cancer: Small papillary thyroid cancers--is BRAF of prognostic value? Nature reviews. Endocrinology 7: 9-10, 2011. [Editorial Material] 
 doi: 10.1038/nrendo.2010.213 PMID: 21160471.
 
15
10.0
39. Boaventura P, Soares P, Pereira D, Teixeira-Gomes J, Sobrinho-Simões M
Head and neck lesions in a cohort irradiated in childhood for tinea capitis treatment. The Lancet infectious diseases 11: 163-4, 2011. [Letter] 
 doi: 10.1016/S1473-3099(11)70047-0 PMID: 21371653.
 
13
17.4
40. Eloy C, Vinagre J, Cameselle-Teijeiro J, Paiva ME, Soares P, Sobrinho-Simões M
Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component? International journal of surgical pathology 19: 276-80, 2011. [Article] 
 doi: 10.1177/1066896910393506 PMID: 21216781.
 
11
1.0
41. Eloy C, Santos J, Soares P, Sobrinho-Simões M
Intratumoural lymph vessel density is related to presence of lymph node metastases and separates encapsulated from infiltrative papillary thyroid carcinoma. Virchows Archiv : an international journal of pathology 459: 595-605, 2011. [Article] 
 doi: 10.1007/s00428-011-1161-3 PMID: 22081104.
 
7
2.5
42. Máximo V, Lima J, Soares P, Sobrinho-Simões M
Mitochondria and cancer. Virchows Archiv : an international journal of pathology 454: 481-95, 2009. [Review] 
 doi: 10.1007/s00428-009-0766-2 PMID: 19343360.
 
40
2.3
43. Cameselle-Teijeiro J, Menasce LP, Yap BK, Colaco RJ, Castro P, Celestino R, Ruíz-Ponte C, Soares P, Sobrinho-Simões M
Cribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior. American journal of clinical pathology 131: 134-42, 2009. [Article] 
 doi: 10.1309/AJCP7ULS0VSISBEB PMID: 19095577.
 
31
2.5
44. Cameselle-Teijeiro J, Abdulkader I, Pérez-Becerra R, Vázquez-Boquete A, Alberte-Lista L, Ruiz-Ponte C, Forteza J, Sobrinho-Simões M
BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? Human pathology 40: 1029-35, 2009. [Article] 
 doi: 10.1016/j.humpath.2008.11.015 PMID: 19269016.
 
28
3.0
45. Preto A, Gonçalves J, Rebocho AP, Figueiredo J, Meireles AM, Rocha AS, Vasconcelos HM, Seca H, Seruca R, Soares P, Sobrinho-Simões M
Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations. BMC cancer 9: 387, 2009. [Article] 
 doi: 10.1186/1471-2407-9-387 PMID: 19878585.
 
26
2.7
46. Couto JP, Prazeres H, Castro P, Lima J, Máximo V, Soares P, Sobrinho-Simões M
How molecular pathology is changing and will change the therapeutics of patients with follicular cell-derived thyroid cancer. Journal of clinical pathology 62: 414-21, 2009. [Review] 
 doi: 10.1136/jcp.2008.055343 PMID: 19147628.
 
17
2.3
47. Celestino R, Magalhães J, Castro P, Triller M, Vinagre J, Soares P, Sobrinho-Simões M
A follicular variant of papillary thyroid carcinoma in struma ovarii. Case report with unique molecular alterations. Histopathology 55: 482-7, 2009. [Letter] 
 doi: 10.1111/j.1365-2559.2009.03401.x PMID: 19817905.
 
14
3.9
48. Soares P, Sobrinho-Simões M
Is BRAF mutation screening useful for preoperative risk stratification in papillary thyroid cancer? Future oncology (London, England) 5: 1225-9, 2009. [Article] 
 doi: 10.2217/fon.09.81 PMID: 19852736.
 
2
-
49. Trovisco V, Couto JP, Cameselle-Teijeiro J, de Castro IV, Fonseca E, Soares P, Sobrinho-Simões M
Acquisition of BRAF gene mutations is not a requirement for nodal metastasis of papillary thyroid carcinoma. Clinical endocrinology 69: 683-5, 2008. [Letter] 
 doi: 10.1111/j.1365-2265.2008.03243.x PMID: 18363883.
 
23
3.4
50. Máximo V, Lima J, Soares P, Silva A, Bento I, Sobrinho-Simões M
GRIM-19 in Health and Disease. Advances in anatomic pathology 15: 46-53, 2008. [Editorial Material] 
 doi: 10.1097/PAP.0b013e31815e5258 PMID: 18156812.
 
18
3.7
51. Cameselle-Teijeiro J, Pardal F, Eloy C, Ruiz-Ponte C, Celestino R, Castro P, Soares P, Sobrinho-Simões M
Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth. Human pathology 39: 1540-7, 2008. [Article] 
 doi: 10.1016/j.humpath.2008.01.014 PMID: 18602667.
 
10
3.3
52. Meireles AM, Preto A, Rocha AS, Rebocho AP, Máximo V, Pereira-Castro I, Moreira S, Feijão T, Botelho T, Marques R, Trovisco V, Cirnes L, Alves C, Velho S, Soares P, Sobrinho-Simões M
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines. Thyroid : official journal of the American Thyroid Association 17: 707-15, 2007. [Article] 
 doi: 10.1089/thy.2007.0097 PMID: 17725429.
 
72
2.7
53. Trovisco V, Soares P, Preto A, Castro P, Máximo V, Sobrinho-Simões M
Molecular genetics of papillary thyroid carcinoma: great expectations. Arquivos brasileiros de endocrinologia e metabologia 51: 643-53, 2007. [Review] 
 PMID: 17891228.
 
26
-
54. Preto A, Soares P, Sobrinho-Simões M
Novas terapêuticas no carcinoma da tireóide: novos alvos moleculares? Mundo Médico 54: 8-12, 2007. [] 
.
 
0
-
55. Castro P, Vieira de Castro I, Rebocho AP, Soares RJ, Magalhães J, Roque L, Trovisco V, Cardoso-de-Oliveira M, Fonseca E, Soares P, Sobrinho-Simões M
PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma. The Journal of clinical endocrinology and metabolism 91: 213-20, 2006. [Article] 
 doi: 10.1210/jc.2005-1336 PMID: 16219715.
 
201
5.8
56. Trovisco V, Soares P, Sobrinho-Simões M
B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas. Human pathology 37: 781-6, 2006. [Article] 
 doi: 10.1016/j.humpath.2006.03.013 PMID: 16784975.
 
57
2.8
57. Cameselle-Teijeiro J, Abdulkader I, Barreiro-Morandeira F, Ruiz-Ponte C, Reyes-Santías R, Chavez E, Sobrinho-Simões M
Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: a case report. International journal of surgical pathology 14: 79-84, 2006. [Article] 
 PMID: 16501842.
 
33
1.0
58. Castro P, Soares P, Gusmão L, Seruca R, Sobrinho-Simões M
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid. Oncogene 25: 4620-7, 2006. [Article] 
 doi: 10.1038/sj.onc.1209491 PMID: 16532025.
 
25
6.6
59. Rocha AS, Risberg B, Magalhães J, Trovisco V, de Castro IV, Lazarovici P, Soares P, Davidson B, Sobrinho-Simões M
The p75 neurotrophin receptor is widely expressed in conventional papillary thyroid carcinoma. Human pathology 37: 562-8, 2006. [Article] 
 doi: 10.1016/j.humpath.2005.12.016 PMID: 16647954.
 
25
2.8
60. Fonseca E, Soares P, Cardoso-Oliveira M, Sobrinho-Simões M
Diagnostic criteria in well-differentiated thyroid carcinomas. Endocrine pathology 17: 109-17, 2006. [Article] 
 PMID: 17159243.
 
21
1.5
61. Trovisco V, Soares P, Preto A, de Castro IV, Lima J, Castro P, Máximo V, Botelho T, Moreira S, Meireles AM, Magalhães J, Abrosimov A, Cameselle-Teijeiro J, Sobrinho-Simões M
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness. Virchows Archiv : an international journal of pathology 446: 589-95, 2005. [Article] 
 doi: 10.1007/s00428-005-1236-0 PMID: 15902486.
 
219
2.2
62. Máximo V, Botelho T, Capela J, Soares P, Lima J, Taveira A, Amaro T, Barbosa AP, Preto A, Harach HR, Williams D, Sobrinho-Simões M
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. British journal of cancer 92: 1892-8, 2005. [Article] 
 doi: 10.1038/sj.bjc.6602547 PMID: 15841082.
 
152
4.1
63. Trovisco V, Soares P, Soares R, Magalhães J, Sá-Couto P, Sobrinho-Simões M
A new BRAF gene mutation detected in a case of a solid variant of papillary thyroid carcinoma. Human pathology 36: 694-7, 2005. [Article] 
 doi: 10.1016/j.humpath.2005.04.011 PMID: 16021577.
 
79
2.6
64. Castro P, Roque L, Magalhães J, Sobrinho-Simões M
A subset of the follicular variant of papillary thyroid carcinoma harbors the PAX8-PPARgamma translocation. International journal of surgical pathology 13: 235-8, 2005. [Article] 
 PMID: 16086077.
 
36
0.9
65. Máximo V, Lima J, Soares P, Botelho T, Gomes L, Sobrinho-Simões M
Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy. Mitochondrion 5: 333-40, 2005. [Article] 
 doi: 10.1016/j.mito.2005.06.003 PMID: 16183030.
 
28
0.8
66. Castro P, Eknaes M, Teixeira MR, Danielsen HE, Soares P, Lothe RA, Sobrinho-Simões M
Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes. The Journal of pathology 206: 305-11, 2005. [Article] 
 doi: 10.1002/path.1772 PMID: 15852498.
 
27
6.2
67. Cameselle-Teijeiro J, Abdulkader I, Soares P, Alfonsín-Barreiro N, Moldes-Boullosa J, Sobrinho-Simões M
Cystic tumor of the atrioventricular node of the heart appears to be the heart equivalent of the solid cell nests (ultimobranchial rests) of the thyroid. American journal of clinical pathology 123: 369-75, 2005. [Article] 
 doi: 10.1309/GWT2-PY0T-77PB-BA1A PMID: 15716232.
 
21
2.9
68. Cameselle-Teijeiro J, Preto A, Soares P, Sobrinho-Simões M
A stem cell role for thyroid solid cell nests. Human pathology 36: 590-1, 2005. [Letter] 
 doi: 10.1016/j.humpath.2005.02.010 PMID: 15948129.
 
19
2.6
69. Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M
Reply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer letters 230: 149-50, 2005. [Letter] 
 doi: 10.1016/j.canlet.2004.10.053 PMID: 16253771.
 
2
3.0
70. Sobrinho-Simões M
Funding of a medical research institute in a small country: 15 years of Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP)--interview conducted by Ivan Damjanov. Croatian medical journal 46: 467-75, 2005. [] 
 PMID: 15861529.
 
0
0.8
71. Sobrinho-Simões M
BRAF Mutations in thyroid carcinomas: phenotype-genotype correlations. Advances in anatomic pathology 12: 106-107, 2005. [] 
.
 
0
2.0
72. Trovisco V, Vieira de Castro I, Soares P, Máximo V, Silva P, Magalhães J, Abrosimov A, Guiu XM, Sobrinho-Simões M
BRAF mutations are associated with some histological types of papillary thyroid carcinoma. The Journal of pathology 202: 247-51, 2004. [Article] 
 doi: 10.1002/path.1511 PMID: 14743508.
 
284
5.3
73. Carneiro F, Huntsman DG, Smyrk TC, Owen DA, Seruca R, Pharoah P, Caldas C, Sobrinho-Simões M
Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening. The Journal of pathology 203: 681-7, 2004. [Article] 
 doi: 10.1002/path.1564 PMID: 15141383.
 
180
5.3
74. Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M
BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. The Journal of clinical endocrinology and metabolism 89: 4267-71, 2004. [Article] 
 doi: 10.1210/jc.2003-032224 PMID: 15356020.
 
130
5.8
75. Soares P, Trovisco V, Rocha AS, Feijão T, Rebocho AP, Fonseca E, Vieira de Castro I, Cameselle-Teijeiro J, Cardoso-Oliveira M, Sobrinho-Simões M
BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas. Virchows Archiv : an international journal of pathology 444: 572-6, 2004. [Article] 
 doi: 10.1007/s00428-004-1018-0 PMID: 15095090.
 
95
2.2
76. Preto A, Cameselle-Teijeiro J, Moldes-Boullosa J, Soares P, Cameselle-Teijeiro JF, Silva P, Reis-Filho JS, Reyes-Santías RM, Alfonsín-Barreiro N, Forteza J, Sobrinho-Simões M
Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 17: 819-26, 2004. [Article] 
 doi: 10.1038/modpathol.3800124 PMID: 15044923.
 
53
3.6
77. Woenckhaus C, Cameselle-Teijeiro J, Ruiz-Ponte C, Abdulkader I, Reyes-Santías R, Sobrinho-Simões M
Spindle cell variant of papillary thyroid carcinoma. Histopathology 45: 424-7, 2004. [Letter] 
 doi: 10.1111/j.1365-2559.2004.01916.x PMID: 15469488.
 
10
3.0
78. Máximo V, Preto A, Crespo A, Rocha AS, Machado JC, Soares P, Sobrinho-Simões M
Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid. BMC cancer 4: 12, 2004. [Article] 
 doi: 10.1186/1471-2407-4-12 PMID: 15043758.
 
4
2.3
79. Magalhães J, Sobrinho-Simões M
Hyalinizing trabecular tumor of the thyroid displaying neuroendocrine differentiation. Virchows Archiv : an international journal of pathology 445: 98, 2004. [Letter] 
 doi: 10.1007/s00428-004-1026-0 PMID: 15138815.
 
2
2.2
80. Carneiro F, Sobrinho-Simões M
Hereditary diffuse gastric cancer: Lessons from histopathology. Advances in anatomic pathology 12: 151-152, 2004. [] 
.
 
0
1.7
81. Carneiro F, Huntsman DG, Smyrk T, Owen D, Seruca R, Pharoah P, Caldas C, Sobrinho-Simões M
Pathology of inherited gastric cancer. Pathol Internat 54: S285-S286, 2004. [] 
.
 
0
1.1
82. Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, Máximo V, Botelho T, Seruca R, Sobrinho-Simões M
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene 22: 4578-80, 2003. [Article] 
 doi: 10.1038/sj.onc.1206706 PMID: 12881714.
 
499
6.5
83. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Castro Alves C, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Simões M
A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 125: 364-71, 2003. [Article] 
 PMID: 12891537.
 
394
12.7
84. Reis-Filho JS, Preto A, Soares P, Ricardo S, Cameselle-Teijeiro J, Sobrinho-Simões M
p63 expression in solid cell nests of the thyroid: further evidence for a stem cell origin. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 16: 43-8, 2003. [Article] 
 doi: 10.1097/01.MP.0000047306.72278.39 PMID: 12527712.
 
84
3.3
85. Rocha AS, Soares P, Fonseca E, Cameselle-Teijeiro J, Oliveira MC, Sobrinho-Simões M
E-cadherin loss rather than beta-catenin alterations is a common feature of poorly differentiated thyroid carcinomas. Histopathology 42: 580-7, 2003. [Article] 
 PMID: 12786894.
 
73
3.0
86. Nabais S, Machado JC, Lopes C, Seruca R, Carneiro F, Sobrinho-Simões M
Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis. International journal of surgical pathology 11: 1-9, 2003. [Article] 
 PMID: 12598910.
 
24
1.0
87. Lima J, Teixeira-Gomes J, Soares P, Máximo V, Honavar M, Williams D, Sobrinho-Simões M
Germline succinate dehydrogenase subunit D mutation segregating with familial non-RET C cell hyperplasia. The Journal of clinical endocrinology and metabolism 88: 4932-7, 2003. [Article] 
 PMID: 14557476.
 
21
5.9
88. Cameselle-Teijeiro J, Manuel Lopes J, Villanueva JP, Gil-Gil P, Sobrinho-Simões M
Lipomatous haemangiopericytoma (adipocytic variant of solitary fibrous tumour) of the thyroid. Histopathology 43: 406-8, 2003. [Letter] 
 PMID: 14511266.
 
19
3.0
89. Lima J, Máximo V, Soares P, Sobrinho-Simões M
Alterations of the SDHD gene locus in midgut carcinoids. Genes, chromosomes & cancer 36: 424, 2003. [Letter] 
 doi: 10.1002/gcc.10147 PMID: 12619155.
 
4
4.2
90. Lima J, Máximo V, Soares P, Williams D, Bogdanova T, Thomas GA, Sobrinho-Simões M
Re: Lohrer,H.D., Hieber,L. and Zitzelsberger,H. (2002) Differential mutation frequency in mitochondrial DNA from thyroid tumours. Carcinogenesis, 23, 1577-1582. Carcinogenesis 24: 1155, 2003. [Letter] 
 doi: 10.1093/carcin/bgg050 PMID: 12807747.
 
1
4.7
91. Carneiro F, Machado JC, Nabais S, Santos CM, Sobrinho Simões M
Mixed carcinoma of the stomach: a clinicopathological entity. Histopathology 43: 94-5, 2003. [Letter] 
 PMID: 12823718.
 
1
3.0
92. Cameselle-Teijeiro J, Sobrinho-Simões M
Carcinoma papilar de la glândula tireoide. Problemas en el diagnostico y controversias. Revista Española de Patologia 36: 373-382, 2003. [] 
.
 
0
-
93. Castro P, David L, Soares P, Carneiro F, Fonseca E, Sobrinho-Simões M
Vascular invasion in thyroid and gastric carcinomas. Ultrastructural pathology 27: 41-8, 2003. [Article; Proceedings Paper] 
 PMID: 12554535.
 
0
0.9
94. Soares P, Máximo V, Sobrinho-Simöes M
Molecular pathology of papillary, follicular and Hürthle cell carcinomas of the thyroid. Arkhiv patologii 65: 45-7, 2003. [] 
 PMID: 15357248.
 
0
-
95. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-Simões M
Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. Journal of the National Cancer Institute 94: 1680-7, 2002. [Article] 
 PMID: 12441323.
 
489
14.5
96. Máximo V, Soares P, Lima J, Cameselle-Teijeiro J, Sobrinho-Simões M
Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors. The American journal of pathology 160: 1857-65, 2002. [Article] 
 PMID: 12000737.
 
192
6.8
97. Ivanova R, Soares P, Castro P, Sobrinho-Simões M
Diffuse (or multinodular) follicular variant of papillary thyroid carcinoma: a clinicopathologic and immunohistochemical analysis of ten cases of an aggressive form of differentiated thyroid carcinoma. Virchows Archiv : an international journal of pathology 440: 418-24, 2002. [Article] 
 doi: 10.1007/s00428-001-0543-3 PMID: 11956824.
 
64
2.0
98. Silva E, Teixeira A, David L, Carneiro F, Reis CA, Sobrinho-Simões J, Serpa J, Veerman E, Bolscher J, Sobrinho-Simões M
Mucins as key molecules for the classification of intestinal metaplasia of the stomach. Virchows Archiv : an international journal of pathology 440: 311-7, 2002. [Article] 
 doi: 10.1007/s004280100531 PMID: 11889603.
 
55
2.0
99. Teixeira A, David L, Reis CA, Costa J, Sobrinho-Simões M
Expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) and type 1 Lewis antigens in cases with and without Helicobacter pylori colonization in metaplastic glands of the human stomach. The Journal of pathology 197: 37-43, 2002. [Article] 
 doi: 10.1002/path.1083 PMID: 12081201.
 
39
4.6
100. Castro P, Fonseca E, Magalhães J, Sobrinho-Simões M
Follicular, papillary, and "hybrid" carcinomas of the thyroid. Endocrine pathology 13: 313-20, 2002. [Article] 
 PMID: 12665649.
 
22
0.4
@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
A
A
A

Send Email
From
To
Subject